Semaglutide vs. Tirzepatide: What’s the Difference?

Written By Jamie Dobrowolski

At Walker Wellness, one of the most common questions we hear from clients interested in medical weight loss is: “What’s the difference between Semaglutide and Tirzepatide?” Both are powerful tools for safe, medically guided weight management—but they work in slightly different ways.

What is Semaglutide?

Semaglutide is a medication in the GLP-1 (glucagon-like peptide-1) receptor agonist family. It works by:

  • Slowing digestion to help you feel full longer

  • Reducing appetite and cravings

  • Supporting balanced blood sugar levels

Semaglutide is the active ingredient in brand-name medications like Wegovy® and Ozempic®. It has been studied extensively and is proven to help with significant weight reduction when combined with lifestyle changes.

What is Tirzepatide?

Tirzepatide is a newer medication that belongs to a dual-acting class. It targets two receptors:

  • GLP-1 (same as Semaglutide)

  • GIP (glucose-dependent insulinotropic polypeptide)

By activating both GLP-1 and GIP receptors, Tirzepatide may provide even greater appetite control, improved insulin sensitivity, and enhanced weight loss results for many patients.

Key Differences

  • Mechanism of Action

    • Semaglutide: Works only on GLP-1 receptors

    • Tirzepatide: Works on both GLP-1 and GIP receptors

  • Effectiveness

    • Both medications support weight loss and blood sugar control

    • Studies suggest Tirzepatide may lead to slightly greater average weight loss for some individuals

  • Side Effects

    • Both may cause mild nausea, digestive changes, or decreased appetite (often temporary)

  • Cost and Availability

    • Pricing varies depending on dosage and compounding

    • At Walker Wellness, we provide both Semaglutide and Tirzepatide with ongoing medical guidance to ensure safety and effectiveness

Which One is Right for You?

The best option depends on your health history, weight loss goals, and how your body responds to treatment. That’s why we start with a comprehensive consultation and lab review, ensuring your plan is safe, customized, and sustainable.

At Walker Wellness, your weight loss journey is guided every step of the way by Tiffany Walker, APRN, FNP-C. With regular check-ins, body scans, and nutritional support, we tailor each program to help you achieve lasting results.

Jamie Dobrowolski
Previous

Weight Loss with GLP-1s
Next

The Benefits of NAD+ IV Therapy